Protein motions lie at the heart of enzyme catalysis. From vibrational motions to conformational changes, distinct types of protein dynamics contribute to catalysis in their unique ways. Our research addresses how protein dynamics contribute to the catalytic activity of enzymes. By modulating these motions, inhibitors, and activators can be designed for innovative drug discovery. Currently, we are exploring how disease-associated mutations alter the conformational dynamics of human proteins involved in rare pediatric diseases.