Research projects
Understanding protein dynamics in enzyme catalysis for drug discovery
Protein motions are embedded in the basis of enzyme catalysis. From vibrational motions to conformational changes, distinct types of protein dynamics contribute to catalysis in their unique ways.
Our research addresses how protein dynamics contribute to the catalytic activity of enzymes. By modulating these motions, inhibitors and activators can be designed for innovative drug discovery.
We are investigating the domain-domain communication in multidomain enzymes to find strategies for developing drugs to treat cancer and other diseases.
Metalloenzymes in the biosynthesis of microbial secondary metabolites
It is estimated that about one-third of enzymes in nature require metal ions to perform their function.
We are interested in gaining a fundamental understanding of molecular processes underpinning the role of the protein environment in modulating the intrinsic reactivity of transition metals in enzymes that can be utilized in future diagnostic and therapeutic applications.
In particular, we are investigating peptide-modifying reactions catalyzed by metal-dependent enzymes as part of developing novel peptide-based antibiotics to fight drug-resistant bacteria.
Join us!
We have an opening for a postdoc position.
Postdoctoral applications can be submitted by email. Click Contact Us to submit your request.